Over 50 years ago now, my friend and colleague, Prof. Ron Schultz, and I were the only two people saying we were over-vaccinating pets. I was called irresponsible in public at a large veterinary conference because others were unwilling to consider the idea that vaccines might not always be needed or safe. Since then, people aren’t shooting arrows at us now because our backs are full of them!  Joking aside, despite the criticism, we were and remain determined to continue to educate about this topic.

Even today, estimates are that only about 40% of veterinarians are following the current WSAVA, AVMA, AAHA and BVA vaccine policy guidelines. *  There is no such thing as an ‘up to date’ or ‘due’ vaccination. Enlightened veterinarians now can offer a package of separated vaccine components, when available, rather than give them all together, since the published data show more adverse reactions when multiple vaccines are administered at the same time.

Summary on Vaccine Policy

AAHA 2003 –  Current knowledge supports the statement that 

  • No vaccine is always safe, no vaccine is always protective and no vaccine is always indicated
  • Misunderstanding, misinformation and the conservative nature of our profession have largely slowed adoption of protocols advocating decreased frequency of vaccination

WSAVA 2015-2017

From Prof. Michael J. Day

  • Vaccination should be just one part of a holistic preventive healthcare program for pets that is most simply delivered within the framework of an annual health check consultation
  • Vaccination is an act of veterinary science that should be considered as individualized medicine, tailored for the needs of the individual pet, and delivered as one part of a preventive medicine program in an annual health check visit

Importantly, pet caregivers should understand that the act of giving a vaccine may not equate to immunization of that animal. Vaccines may not always produce the needed or desired immune protective response, not only if the vaccine itself was inadequately prepared (very rare) but also if the pet is a genetic low or non-responder to that vaccine (quite common in certain breeds of dogs and their families).  In the latter case, that pet will be susceptible lifelong to the disease of concern and revaccination will not help and could even be harmful.  

In response to issues raised above, vaccine experts recently have recommended new protocols for dogs and cats. These include: 1) giving the puppy or kitten vaccine series later (starting  not before 8 weeks of age, except in the cases of outbreaks of virulent viral disease or in orphans or those that never received colostrum from their dams) followed by a booster at one year of age; 2) administering further boosters in a combination vaccine every three years or as split components alternating every other year until; 3) the pet reaches geriatric age, at which time booster vaccination is likely to be unnecessary and can be unsafe for those with aging-related or immunologic disorders. 

In the intervening years between booster vaccinations, and in the case of geriatric pets, circulating humoral immunity can be evaluated by measuring serum vaccine antibody titers as an indication of the presence of immune memory (e.g. VacciCheck). Titers do not distinguish between immunity generated by vaccination and/or exposure to the disease, although the magnitude of immunity produced just by vaccination is usually lower.

When to Vaccinate Puppies & Kittens? Which Vaccines are Needed? What About Socialization?

Puppies

  • Should receive MLV or recombinant “Core” vaccines (canine distemper, parvovirus and hepatitis/adenovirus) preferably either at 9-10 and 14-16 weeks of age (minimum protocol), or, at 9, 12 and 16-18 weeks of age
  • Rabies vaccines are all adjuvanted killed products and are given as required by law, preferably always given separately from other vaccines, and as late as legally allowed – e.g. 20-24 weeks of age. Thimerosal (mercury) - free rabies vaccines are preferred and safer
  • Other vaccines are optional, and depend upon circumstances and disease risk in the area
  • For the optional Bordetella or kennel cough vaccines, the oral version is preferred over the intranasal although both offer better protection than the injectable version
  • Leptospirosis vaccines protect against only 4 serovars of the organism and are second to rabies vaccines in risk of hypersensitivity and other adverse effects. Use if endemic in the area of concern
  • While canine influenza viruses (2 strains; H3N2 and H3N8) are highly contagious, most infected dogs have mild to no clinical issues, unless they develop a high fever and are at risk for secondary pneumonia. Vaccination, while being widely promoted, is still optional
  • Three or more days after the last round of puppy vaccines, they can be out and about to be socialized. In the interim period, between 10-14 weeks of age, socialization can take place in the back yard or at puppy training classes with known friends and healthy dogs
  • Until fully vaccinated, puppies should not walk on unfamiliar or public grounds; they can be carried about, when needed to travel
  • If Titer testing is desired, instead of giving another vaccine after 12 weeks of age, wait until at least 16 weeks of age to avoid measuring residual maternal immunity

Kittens

  • Core vaccines (feline panleukopenia, feline calicivirus, feline rhinotracheitis/herpes) given as MLV or killed, inactivated or intranasal products are started in a 2 or three-dose series beginning for example at 7-9 weeks of age and 12-16 weeks, or at 7, 11 and 16 weeks
  • Rabies vaccines if legally required are recommended as for puppies, although cats can receive a recombinant non-adjuvanted rabies vaccine which is preferred over the adjuvanted killed rabies vaccines given to dogs. This non-adjuvanted rabies vaccine is not yet available for dogs
  • Some people consider feline leukemia virus (FeLV) vaccine as important for cats, especially those that live outdoors or are indoor/outdoor. Options are a recombinant non-adjuvanted or a killed adjuvanted vaccine
  • Feline immune deficiency virus (FIV) vaccine is available in an adjuvanted killed virus vaccine for those cats at similar exposure risk to FeLV.
  • Other vaccines (Chlamydia, FIP) are generally not recommended or are optional, and depend upon circumstances and disease risk in the area
  • Socialization and Vaccine Titer testing options are as for puppies

*WSAVA-World Small Animal Veterinary Association; AVM A- American Veterinary Medical Association; AAHA-, American Animal Hospital Association; BVA-  British Veterinary Association

Published in Blog
Wednesday, 08 August 2018 11:35

VacciCheck for disease detection

A vet, having encountered a large number of kittens suspected of Panleukopenia (FPV), approached us at Biogal. The kittens in question were of a private home cattery. The owner noticed that two of the kittens were in a very poor condition. The two sickly kittens were brought to the clinic for hospitalization with a suspicion of FPV. None of the kittens had been vaccinated.

The suspected disease was due to a compatible blood results (Low white blood cells) and suggestive clinical signs.

Slowly, at the cattery, other kittens began to show signs of lethargy, diarrhoea and a lack of appetite.

Feline Panleukopenia Virus (FPV), also known as Feline Infectious Enteritis, Feline Parvoviral Enteritis and Feline Ataxia, is a viral infection affecting cats. It is caused by Feline Parvovirus, Fast progressive with an incubation time of ~2-10 days, highly contagious and can be fatal. The name Panleukopenia comes from the low white blood cell count (Leucocytes) exhibited by affected animals.

Knowing how fatal and highly contagious FPV can be, the owner knew that something had to be done for the sickly and the still healthy kittens. Early treatment and possible isolation of the unaffected kittens, would be wise.

She was glad to hear that the exposed kittens could be differentiated from the healthy ones by using Feline VacciCheck, a simple in-house blood test.

Feline VacciCheck measures IgG antibodies specific to FPV. IgG antibodies rises within days to weeks after exposure to the disease or to vaccination and persist for a long period. In cases with no vaccination history and suggestive clinical signs of the disease the presence of IgG can support the diagnosis.

In young kittens the presence of IgG could be from Maternally Derived Antibodies (MDA). The MDA passively pass to the kittens through colostrum on their first hours of life and disappears within a few weeks from their blood stream.

In this case none of the kittens had been vaccinated. Most of the kittens were estimated to be around 5 months old, where the presence of MDA is less likely. Therefore, the presence of IgG antibodies probably will indicate exposure and will require a close monitoring of the kittens who are at risk and proper disinfection actions to the whole cattery.

Feline VacciCheck testing was run on eleven kittens in the cattery:

 

The other two antibodies tested are two highly contagious respiratory diseases: Feline Herpes Virus (FHV) and Feline Calici Virus (FCV).  

The kittens who showed positive results to all the 3 pathogens, are perhaps those with MDA presence (younger kittens) or those who were exposed to all these 3 diseases (which is very likely in a very crowded cattery).

The two negative FPV kittens were isolated from the others. The whole cattery was properly disinfected with solution of diluted bleach.

All the other kittens, positive FPV IgG, were closely monitored. Being positive means that they had been exposed to the disease but would not necessarily develop the disease. This would depend on the individual immune system of each kitten.

After further investigation, these results were validated using a PCR (Biogal PCRun) technic which confirmed the presence of the panleukopenia virus in all positive kittens.

In total, five out of the nine positive kittens who were closely monitored showed clinical signs and were treated promptly. Thanks to early diagnosis and treatment, the recovery was quick and successful for all five kittens.

Published in Blog

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